Five Acts. Three Weeks. One Very Good Month for Comedy.
September 2026 spreads its comedy across the full month -- two nights early in September at Caesars, a single evening at MGM Grand the same weekend, two nights at the Wynn toward the end of the month, and a mid-month weekend where Kathy Griffin and Greg Gutfeld both perform on the same night at different venues. None of these overlap in a way that forces you to choose except for September 5 and September 19, and even then the choice is between two genuinely different kinds of evening. Five acts, no residency padding, all of them worth paying attention to.
Nikki Glaser and David Spade at The Colosseum, Caesars Palace
Nikki Glaser and David Spade at The Colosseum is the most interesting pairing on this list. Glaser has spent the past few years building a reputation as one of the sharpest working comedians -- her material is personal, precise, and delivered with the kind of confidence that comes from knowing exactly what you are doing on a stage. Spade has been a fixture of American comedy for thirty-plus years, with a deadpan style that has only gotten more economical with time. The two of them together at The Colosseum -- a venue built for headliners -- is a bill that earns the room. Two nights: September 4 and 5 at 8:00 PM. Ages 6 and up.
When: September 4 & 5, 2026 at 8:00 PM | Venue: The Colosseum, Caesars Palace | Age: 6+
Jay Leno at MGM Grand Theater
Jay Leno at MGM Grand is September 5 at 9:00 PM -- one night, and a scheduling note: this is the same evening as Nikki Glaser and David Spade at Caesars, so if you are in Las Vegas that Saturday, you have a genuine choice to make. Leno is a performer who has been working rooms for fifty years and knows exactly what a Las Vegas audience wants from a Saturday night. His material stays in the observational tradition that built him, and the MGM Grand Theater is a well-suited room for a comedian of his scale. Ages 16 and up.
When: September 5, 2026 at 9:00 PM | Venue: MGM Grand Theater | Age: 16+
Greg Gutfeld at Lee's Family Forum, Henderson
Greg Gutfeld at Lee's Family Forum is September 19 at 7:00 PM -- off the Strip, in Henderson, and running two hours rather than the ninety-minute standard of most comedy bookings in Las Vegas. Lee's Family Forum is a mid-size arena venue about fifteen minutes from the Strip by rideshare, and the crowd it draws for a show like this tends to be energized in a way that a Strip theater crowd sometimes is not. Gutfeld has built a substantial following through television and his live shows reflect an audience that showed up specifically for him. One night only, no stated age restriction.
When: September 19, 2026 at 7:00 PM | Venue: Lee's Family Forum, 200 S Green Valley Pkwy, Henderson | Duration: 2 hours
Kathy Griffin at Criss Angel Theater, Planet Hollywood
Kathy Griffin at Planet Hollywood is also September 19 at 8:00 PM -- which puts her on the same night as Gutfeld at Lee's Family Forum and Scorpions at PH Live across the Strip. The Criss Angel Theater at Planet Hollywood is an intimate room by Strip standards, which suits Griffin's style: she is a comedian who has always performed better when the distance between her and the crowd is short. Her material has always been sharpest in a live setting, and one night is all Las Vegas gets from her in September.
When: September 19, 2026 at 8:00 PM | Venue: Criss Angel Theater, Planet Hollywood
Ali Wong at the Encore Theater, Wynn Las Vegas
Ali Wong at the Encore Theater closes out the month with two nights -- September 25 and 26 at 8:00 PM -- and is the strongest pure stand-up pick on this list if you want to see a comedian operating at the peak of her craft. Wong's material is fully formed, aggressively personal, and delivered with a physical commitment that makes the written word feel inadequate as a description. She has been one of the most acclaimed comedians working for years, and the Encore Theater at Wynn gives her a room that matches the quality of the performance. Two nights means a Friday and a Saturday option -- both worth taking seriously before they sell out. Ages 12 and up.
When: September 25 & 26, 2026 at 8:00 PM | Venue: Encore Theater, Wynn Las Vegas | Age: 12+
The Practical Truth
Five acts across three weeks, with two scheduling conflicts worth knowing: September 5 puts Nikki Glaser and David Spade at Caesars against Jay Leno at MGM Grand. September 19 puts Kathy Griffin at Planet Hollywood against Greg Gutfeld in Henderson -- and Scorpions at PH Live for anyone whose evening could go either way. Every other date in September is clear. Check the booking section below for current availability across all five shows.
